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The biologic significance of this finding is unknown. Factor XIIIa Positive Control Slides , Product No. 251S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Other Notes For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com Newcomer Supply Factor XIIIa (fibrin stabilizing factor) Control Slides are for the positive immunohistochemical staining of Factor XIIIa, a blood coagulation enzyme that crosslinks fibrin. Factor XIIIa is used as a marker for fibro-histiocytic proliferations, dermal dendritic cells and to differentiate dermatofibroma from dermatofibrosarcoma. ical aid to the diagnosis of the most frequent type of EDS. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable. The biologic significance of this finding is unknown.

Factor xiiia positive

Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas. Fullen DR(1), Headington JT. Author information: (1)Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA. Comment in J Cutan Pathol. 1999 May;26(5):263-4. Factor XIIIa Positive Control Slides suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections); find Sigma-Aldrich-251S MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.

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They were also observed associated with epithelial structures in lung and kidney, but were only rarely observed in liver, thyroid, testis and spleen. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Involvement in disease.

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By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable. The biologic significance of this finding is unknown.

SOTTO, Mirian Nacagami - Dendrócitos dérmicos fator XIIIa positivos na resposta tecidual cutânea da … Comparison of Angiomyofibroblastoma and Aggressive Angiomyxoma in Both Sexes: Four Cases Composed of Bimodal CD34 and Factor XIIIa Positive Dendritic Cell Subsets. Author links open overlay panel Jeffrey S. Silverman 1 2 Jak Albukerk 1 2 Ali Tamsen 1 2. Show more. Share. Cite. Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000.
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Factor XIIIa Positive Control Slides suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections); find Sigma-Aldrich-251S MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin.

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Regulation of hematopoiesis in the freshwater - Diva Portal

Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors (3,4). Factor XIII a-positive DD may be altered in some genetic disorders affecting the connective tissue structure [15,17,20–26]. There is ample evidence that many, if not all, of these disorders are associated with alterations in the tensile properties of the dermis. In addition, a link between Factor XIII a-positive DD and intratissular mechanical Factor XIIIa >95% extensive Factor XIIIa 75% but focal and weak CD34 and Factor XIIIa are difficult to interpret in many cases because of numerous entrapped reactive cells Relationship of factor XIIIa-positive dermal dendrocytes to Kaposi's sarcoma.

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Physical form Paraffin embedded tissue section mounted on microscope slide Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency.

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Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. AFX showed sparse populations of FXIIIa+ cells in the stroma (mean score = 1.33 or 10-25% positive), which were distinct from the atypical giant cells characteristic of these tumors. Keloid similarly contained trapped FXIIIa+ cells (mean score = 0.44 or < 5% positive) that were distinct from the spindle-shaped fibroblasts of the tumor mass. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm.

Factor XIIIa Positive Control Slides , Product No. 251S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Other Notes For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com Newcomer Supply Factor XIIIa (fibrin stabilizing factor) Control Slides are for the positive immunohistochemical staining of Factor XIIIa, a blood coagulation enzyme that crosslinks fibrin. Factor XIIIa is used as a marker for fibro-histiocytic proliferations, dermal dendritic cells and to differentiate dermatofibroma from dermatofibrosarcoma. ical aid to the diagnosis of the most frequent type of EDS. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable.